One major function of chaperones is to prevent both newly synthesised polypeptide chains and assembled subunits from aggregating into nonfunctional structures.
His work on antibody folding delivered important insight in the mechanisms of how antibodies fold and are scrutinized by the cellular chaperone machinery.
Decrypting and reprogramming the chaperone code represents a gigantic initiative that generates new hopes for the development of therapeutics for degenerative diseases.
