ribonuclease dans le dictionnaire Oxford-Hachette

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ribonuclease
anglais d'Amérique

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anglais
In 1967, he determined the molecular structure of the enzyme ribonuclease.
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The best-known example is the ribonuclease inhibitor, but other proteins such as the tropomyosin regulator tropomodulin and the toll-like receptor also share the motif.
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Its function is to inhibit the ribonuclease activity of its binding partner barnase, with which it forms an extraordinarily tightly bound complex within the cell until barnase is secreted.
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Multiple in vitro substrates for thioredoxin have been identified, including ribonuclease, choriogonadotropins, coagulation factors, glucocorticoid receptor, and insulin.
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The molecule, a type of ribonuclease, is found to latch onto the surface glycoproteins of a cancer cell, allowing it to enter and destroy the cell.
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Such proteins interact with bilayers only electrostatically, for example, ribonuclease and poly-lysine interact with membranes in this mode.
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Human angiogenin diverged from ribonuclease, for example, and while the two paralogs remain similar in tertiary structure, their functions within the cell are now quite different.
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The comparatively simple 124-amino acid structure of ribonuclease made it a logical target for the first enzyme to synthesize.
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Removal of this residue through mutation increases the ribonuclease activity between 11 to 30 fold.
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A well-characterised example of this is the ribonuclease inhibitor, which binds to ribonucleases in one of the tightest known proteinprotein interactions.
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